Medium for producing demethylchlortetracycline by fermenting streptomyces aureus and culturing method

一种利用金色链霉菌发酵生产去甲基金霉素的培养基和培养方法

Abstract

本发明涉及一种利用金色链霉菌发酵生产去甲基金霉素的培养基和培养方法,其培养基组成中含有鱼油、糖蜜混合物、蚯蚓粉混合物、蛋白胨等。本发明通过优化培养基配方及发酵工艺,使得去甲基金霉素的平均发酵单位在13000mg/L以上,同国内常规发酵水平相比,提高了10%以上,发酵周期控制在180h以下,缩短发酵周期15h以上,节能降耗,降低生产成本,并且最大限度的降低原辅料来源不受环境影响,保证其供应充足,实现去甲基金霉素稳定、高效的生产。
The invention relates to a medium for producing demethylchlortetracycline by fermenting streptomyces aureus and a culturing method, wherein the medium is composed of fish oil, a molasses mixture, earthworm powder, peptone and the like. By optimizing the medium formula and the fermentation technology, the average fermentation unit of demethylchlortetracycline is 13000 mg/L and improved by 10% or more compared with domestic conventional fermentation level; the fermentation period is controlled at 180 h or less and is shortened by 15 h or more, so that energy is saved, consumption is reduced and production cost is reduced; and also the environmental influence on sources of raw materials and auxiliary materials is furthest reduced, and the raw materials and the auxiliary materials are guaranteed to be sufficiently supplied, so that the stable efficient production of demethylchlortetracycline is realized.

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